We are seeking for highly motivated Associate Scientist to complement our Discovery Biology team in Flanders, Belgium. The successful candidate will join a dynamic, multi-disciplinary team of scientists in exploratory immuno-oncology, playing a key role in the evaluation and understanding of new drug concepts in vitro and in vivo.
Your key responsibilities:
Conduct methods of in vivo experimentation, including tumor implantation, dosing, proper handling of chemotherapeutics, tumor measurement, health monitoring, and data collection and analyses.
Conduct in vitro human and ex vivo mouse immunology experiments to support ongoing immune-oncology portfolio including assays using cancer cell, myeloid and T-cell based co-cultures. Tumour cell biology analysis including analysis of PDX lines and tumour dissociated material.
Assist with design, execution, interpretation and reporting for in vivo syngeneic tumour model studies, to analyse efficacy of both intra-tumoral and systemic interventions.
Maintain detailed and organized experimental records and stay compliant on all relevant internal and external training requirements.
Application of diverse expertise in cellular and molecular biology (e.g. cell/organoid culture, compound screening, FACS, ELISA, western blotting, qRT-PCR, cell transfections & transductions, viral productions).
Support discovery biology team with experimental set-up, assay optimization , analyze data using appropriate statistical methods and preparing data for presentation-ready format.
A minimum of a Bachelor’s degree in Life Sciences (such as Biology, Biochemistry, Pharmacology, Tumor Immunology) with a minimum of 3 to 5 years of relevant laboratory-based experience in industry/biotech or an academic setting is preferred. OR a Master’s degree (M.S.) with relevant pharmaceutical or biotech industry/ lab/ academic experience is required.
Experienced with animal handling in oncology-relevant rodent models such as subcutaneous and orthotopic tumor implantation techniques and dosing, proper handling of therapeutics, tumor measurement, health monitoring, and data collection and analysis required.
Experience with the adherence to animal welfare and compliance regulations is required.
Drug administration by subcutaneous, intraperitoneal, intravenous tail vein injections and oral gavage. Blood collection by tail vein, saphenous vein and cardiac puncture. Perform animal autopsy/dissection and microsurgery, perfusion and tissue collection.
Experienced with cell culture of cancer or immune cells is preferred.
Experienced with bioluminescent imaging, flow cytometry, IHC, ELISA is preferred.
This position may require occasional weekend, evening, and holiday dosing/animal monitoring.
Must have excellent interpersonal skills, with the ability to interact effectively with people.
Must have strong organizational, data management, and record-keeping skills.
The ability to handle several projects simultaneously is preferred.
Must have excellent verbal and written communication skills in English
Hiring will be contingent upon completion of laboratory animal research training courses accredited by the Federation of Laboratory Animal Science Associations (FELASA category B or C) or similar foreign certification.
Knowledge of Microsoft Office and Graphpad Prism.
Learning agility and ability to work across projects highly desirable
About the company
World leader in engineering and R&D services, Capgemini Engineering combines its broad industry knowledge and cutting-edge technologies in digital and software to support the convergence of the physical and digital worlds. Coupled with the capabilities of the rest of the Group, it helps clients to accelerate their journey towards Intelligent Industry. Capgemini Engineering has more than 55,000 engineer and scientist team members in over 30 countries across sectors including Aeronautics, Space, Defense, Naval, Automotive, Rail, Infrastructure & Transportation, Energy, Utilities & Chemicals, Life Sciences, Communications, Semiconductor & Electronics, Industrial & Consumer, Software & Internet.
Capgemini Engineering is an integral part of the Capgemini Group, a global leader in partnering with companies to transform and manage their business by harnessing the power of technology. The Group is guided every day by its purpose of unleashing human energy through technology for an inclusive and sustainable future. It is a responsible and diverse organization of over 340,000 team members in more than 50 countries. With its strong 55-year heritage and deep industry expertise, Capgemini is trusted by its clients to address the entire breadth of their business needs, from strategy and design to operations, fueled by the fast evolving and innovative world of cloud, data, AI, connectivity, software, digital engineering and platforms. The Group reported in 2021 global revenues of €18 billion.